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Participants on the highest dose lost up to 24.2% of body weight over 48 weeks

Because Pendulum can increase GLP-1 production, and GLP-1 affects insulin secretion, combining the supplement with insulin or sulfonylureas could theoretically increase hypoglycemia risk

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Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin Informpatients that the risk of hypoglycemia is increased when BYDUREON is used in combination with an agent that induces hypoglycemia, such as a sulfonylurea or insulin

On a mechanistic level, liraglutide influenced both the expression and functional activity of cardioprotective genes in the murine heart, including Akt, GSK3, PPAR/, Nrf2, and HO-1 (21)