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Biotechnol Bioeng 2021;118:1393404

Reimer RA, Darimont C, Gremlich S, Nicolas-Mtral V, Regg UT, Mac K

This article examines the link between GLP-1 agonists and gallstone formation, explores the underlying mechanismsincluding rapid weight loss and altered gallbladder motilityand provides practical guidance on recognising symptoms, reducing risk, and knowing when to seek medical advice
These results suggest that the gut microbiota, the gut microbiota-derived NMN, and the intestinal NAMPTNAD + SIRT axis collaborate to regulate intestinal homeostasis and systemic metabolic functions (Figure

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