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Wegovy may affect the way some medicines work and some medicines may affect the way Wegovy works

In one study, participants who followed an exercise programme maintained their weight even a year after the programme ended, while those who relied on medication alone were more likely to regain weight.[8] Current guidance from the World Health Organisation recommends aiming for at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity physical activity per week, plus two sessions of muscle-strengthening exercises.[9] Research shows that people who receive continued professional support after losing weight are more likely to maintain their results long-term.[10] When you come off GLP-1 medication, appetite, routine and motivation can all begin to shift, and working with a healthcare professional, dietitian or fitness specialist can help you navigate this transition

J Epidemiol Community Health 2004;58(8):635641

Also, read the accompanying editorial by David Felson: Source Reference: Felson DT "Glucagon-like peptide-1 receptor agonists and osteoarthritis" N Engl J Med 2024

So those approved titration schedules are the evidence-based doses, he says