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Objective The objective of this narrative review is to examine the physiological and clinical evidence regarding the potential role of testosterone replacement therapy in preserving lean mass among men with persistently low serum testosterone levels undergoing GLP-1 receptor agonist-associated weight loss

Dual-energy X-ray absorptiometry (DEXA) provides a full-body view of: Visceral fat the hard-to-see belly fat linked to metabolic risk

For weight management without diabetes, the role of metformin is less established and stopping it may be appropriate if tirzepatide alone is achieving your goals

Images were collected using a nanozoomer digital slide scanner (Hamamatsu) and analysed in NDP.view 2 software (Hamamatsu)

ORO extraction and calorimetric estimation All steps of the ORO staining protocol were carefully followed up until the first wash with PBS after the ORO staining step