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It is unclear why directionality would vary between studies, although we note these studies were performed in specific disease contexts, and are in substantially smaller samples

We don't prescribe for patients who don't meet criteria or have contraindicationsit's a medical decision, not a cosmetic one

The risk of worsening heart failure events alone dropped by 46% (HR 0.54)

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, et al

Early GLP-1 therapy is gaining attention as clinicians rethink traditional treatment timelines
