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However, especially in patients with type 1 diabetes mellitus, dose adjustment is a dynamic process and insulin might require titration to be increased by 1020% or the time of administration to be changed from evening to the morning to achieve the therapeutic goals [26]

True GLP-1 agonists (semaglutide, tirzepatide) are prescription medications that directly bind the GLP-1 receptor

Figure 1 summarizes the key effects of GLP-1 on target tissues

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If symptoms have not improved after 8 weeks at a stable dose, talk to your clinician about adjusting your dose schedule