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In the trials, individuals with diabetes lost less weight with these medications than those without diabetes

However, the cardiovascular outcomes trial (SURMOUNT-MMO) remains ongoing, so we cannot yet confirm whether these surrogate improvements translate to reduced events

As of early 2025, well over 30 new GLP-1 drugs are in development

TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement

As GLP-1 in albiglutide requires an available N-terminal end for engagement with the GLP-1 receptor (GLP-1R) 66,67 , albumin is fused to the C-terminal end of the peptide