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We found genetic evidence suggesting a causal relationship between GLP1RA and a reduced risk of schizophrenia [OR (95% CI) = 0.84 (0.710.98), I 2 = 0.0%, common effects model]

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To estimate the combined uncertainty in outcomes, we performed probabilistic sensitivity analyses using 1000 Monte Carlo simulations based on the uncertainty in the model variables, drawing model variables randomly from the distributions in Table 1
Exenatide formulations show variable nausea rates: the twice-daily immediate-release preparation (Byetta) tends to produce higher rates of nausea (approximately 3050%), whilst the once-weekly extended-release formulation (Bydureon) demonstrates improved tolerability with nausea rates of approximately 1424%, according to their respective SmPCs
Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG, et al
