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For cost-sensitive individuals, this timing dynamic matters: cheaper semaglutide options may arrive around the same time retatrutide launches at full price

Many patients report feeling satisfied with smaller portions and experiencing reduced food cravings, particularly for sweets and high-calorie foods

In clinical trials where a GLP-1 RA was added to background basal insulin, a general 20% basal insulin reduction in all patients or a 20% reduction in patients with an A1C 8.0%, the GLP-1 RA can be reasonably initiated without a reduction in the basal insulin dose for many patients

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Peptides 100 , 190201 (2018)