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The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)

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Weight outcomes track that discontinuation curve exactly: patients who never discontinue lose roughly 11.9% body weight at one year in the real world

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2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension