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doi: 10.1124/jpet.300.3.958

The superiority of a GLP1RA versus placebo has been demonstrated in LEADER,2 HARMONY3 and REWIND,4 and noninferiority demonstrated in EXSCEL35 and ELIXA.36 Subjects CV risk in these trials varied from all having established CVD (HARMONY) to only one third having established CVD (REWIND)

Understanding these causes can help in taking preventive measures

Existing research suggests that fatfree mass (FFM) accounts for approximately twothirds of weight loss during prolonged fasting and that FFM rapidly recovers upon food reintroduction, suggesting that much of the loss may reflect reductions in glycogen and associated fluid rather than lean tissue