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10.1186/s12872-021-02030-5 2 BalestrieriM

For developers of novel MASH therapeutics, the biopsy-confirmed GAN DIO-MASH mouse model serves as a critical translational tool for preclinical efficacy validation

The top six groups of psychiatric AEs with the highest number of reports were insomnia ( n = 1,198, 11.70%), anxiety ( n = 1,131, 11.04%), nervousness ( n = 941, 9.19%), depression ( n = 770, 7.52%), stress ( n = 770, 7.52%), and confusional state ( n = 689, 6.73%)

In addition, bacterial extracellular vesicles (EV) mediate signal transmission between the gut microbiota and the host (Villard et al., 2021)

Maybe, maybe one of the newer ones will come out