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Mark Swain, Hepatologist, Professor of Medicine, University of Calgary: " Having treatment options in this patient population is extremely needed because the disease affects a large population, has a high risk of severe complications like liver cirrhosis and cancer, and lacks effective treatments

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If you stop, the condition it was managing tends to return

However, both medications can cause gastrointestinal side effectsmetformin may cause diarrhea or nausea, while semaglutide can slow digestion and reduce appetiteso your provider should monitor your tolerance during the initial weeks of treatment

A drop of more than 0.5kg lean mass monthly signals insufficient protein intake or excessive energy deficit