repurposing semaglutide and liraglutide for alcohol use disorder GLP-1 receptor agonists disorder: a systematic review meta-analysis | Diabetology & Metabolic Syndrome GLP-1s Hold Promise as Treatment

Lingvay I, Sumithran P, Cohen RV, le Roux CW

"There are some [people] that, despite doing all of this, might have difficulty losing weight, and for those, I recommend talking to a provider to review the variety of medications and interventions that might help."

This is also why constipation is so common on these drugs, affecting an estimated 5 to 24% of users : less fiber and less fluid meet a slowed gut all at once

A wet injection site can cause the medication to disperse unevenly and may introduce bacteria

The GIPR rs1800437 variant influences glucose-dependent insulinotropic peptide (GIP) sensitivity, and MC4R rs17782313 affects melanocortin signalinga master regulator of energy balance