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The STEP 1 trial (Wilding et al., The Lancet, 2021) showed an average weight loss of 14.9% over 68 weeks versus 2.4% in the placebo group a landmark result that established semaglutide as the benchmark for GLP-1 weight loss

When your gut is functioning at its best, your motility is regular and routine, which allows the microbes that are always present, such as bacteria and archaea, to exist in balanced, healthy quantities. One of the most consistent findings in humans is that GLP-1 signaling slows gastrointestinal motility

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4G,I) in Ghsr- and Glp1r- expressing NG neurons, respectively