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To summarize several meta-analyses of CVOTs conducted with GLP-1RAs, it isconfirmed that based on 43 trials, GLP-1RAs are a class of efficacious agent for reducing MACE (MH-OR 0.87 [0.83, 0.92]), cardiovascular and all-cause mortality (MH-OR 0.89 [0.83, 0.96]) [48]

Based on cohort studies of patients with obesity (irrespective of diabetes status) who were newly started on tirzepatide or semaglutide, tirzepatide is associated with significantly more weight loss than semaglutide [102]

Achieving such lifetime perspective inferences solely through real-world research would be exceptionally challenging

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