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GLP-1R activation exerted antifibrotic effects by blocking the interaction between the NLPR3 inflammasome and PFKFB3-driven glycolysis, leading to the inhibition of lactate production and subsequent histone lactylation, and thereby decreasing profibrotic gene expression in fibroblasts under inflammatory stress

However, it's worth noting that because A1C reflects roughly three months of average blood sugar, a 12-week study is arguably too short to capture the full effectiveness a limitation the study authors also mentioned

While there is no cure, the condition can be managed effectively with the right treatment plan and lifestyle support

In: Talley NJ, GR Locke, Saito YA, editors

This has resulted in the number of American adults taking GLP-1s increasing by 587% over the last five years