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Recent studies have demonstrated that weight loss is crucial for not only treating obesity but also for related diseases such as cardiovascular disease, diabetes, and stroke

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December 20, 2019

More recent data highlight the role of GLP-1Rs in the lateral septum, as their targeted knockdown reduces liraglutides ability to inhibit feeding and reduces body weight, evidencing the role of these neurons in the control of energy homeostasis and in the modulation of liraglutide effects [38]

Interestingly, research on vildagliptin indicates that DPP4 inhibition may also improve insulin sensitivity in type 2 diabetes, as shown through indirect assessments of insulin sensitivity [52] and the hyperinsulinemic euglycemic clamp test [60]