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38 This will test whether people with obesity plus heart failure with preserved ejection fraction, randomised to tirzepatide or placebo for 52 weeks, improve a composite endpoint of mortality, heart failure events, exercise capacity, and heart failure symptoms

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Use this baseline to track what changes as your dose stabilizes, then create a detailed maintenance plan during month 3 or 4 of treatmentbefore you begin tapering

This medication is not for treating type 1 diabetes or a condition called diabetic ketoacidosis

Pharmacogenetic studies and meta-analyses support the role of polymorphisms in the SLC6A4 promoter region (5-HTTLPR) and related methylation patterns in moderating antidepressant response and risk of adverse effects, although effect sizes are modest and findings vary by ancestry and study design [25,26]