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Wang Y, Perfetti R, Greig NH, Holloway HW, DeOre KA, Montrose-Rafizadeh C, et al

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Doubling the dose roughly doubles the plasma level, which is a useful property for titration planning

In the early stages of AD, mitochondria are unable to produce enough energy due to A peptides and phosphorylation of tau, and therefore impaired mitochondria eventually cause excessive production of ROS (70)

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