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Description
That is exactly the population in which a GLP-1 add-on or substitution becomes relevant
The resulting increase in intracellular cAMP activates protein kinase A (PKA) and exchange protein activated by cAMP 2 (Epac2)
The conversion chart helps align equivalent doses, but most prescribers recommend starting semaglutide at a lower dose and titrating up regardless of previous tirzepatide dose to minimize gastrointestinal side effects during the transition
Therefore, patients with T2MD are more likely to suffer from several malignancies compared with healthy individuals
2019;15 doi: 10.1016/j.obmed.2019.100115
