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Abbreviations GLP-1: glucagon-like peptide 1 GIP: glucose-dependent insulinotropic polypeptide [Ca 2+ ] i : intracellular Ca 2+ concentrations Adcy: adenylate cyclase CICR: Ca 2+ -induced Ca 2+ release T2D: type 2 diabetes mellitus NOTES

Because of these combined effects, portion sizes naturally become smaller and people find they can no longer finish meals they previously considered normal

Originally developed to manage diabetes, these drugs, known as GLP-1 receptor agonists, have shown remarkable success in helping people lose weight

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Nonetheless, relative to the pace of therapeutic advancements in endocrine and metabolic diseases, such revisions are of secondary priority with greater emphasis placed on the continued clinical impact of these agents in improving patient outcomes