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Franx BAA, Arnoldussen IAC, Kiliaan AJ, Gustafson DR

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Phase 2 Metabolic Benefits Beyond weight loss, retatrutide improved cardiometabolic markers: Blood pressure: Systolic BP decreased 7.4 mmHg (12mg dose) Triglycerides: Reduced 27% from baseline Fasting glucose: Decreased 13.8 mg/dL HbA1c: Reduced 0.4% (in participants without diabetes) TRIUMPH-4: Phase 3 Breakthrough (December 2025) TRIUMPH-4 was the first Phase 3 trial to report