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Description
GLP-1 medications: Increase insulin secretion Decrease glucagon release Slow gastric emptying Reduce appetite and hunger signaling Act on receptors in the central nervous system GLP-1 receptor activity in the brain, pancreas, liver, stomach, and adipose tissue, reinforce that these medications affect more than weight alone

these are usually taken with food, often once daily with the evening meal, but dosing should follow the specific product's Summary of Product Characteristics (SmPC) or British National Formulary (BNF) guidance

There is no absolute contraindication to using GLP-1 receptor agonists in patients with Hashimoto's thyroiditis

The Gut-Nervous System Connection GLP-1 receptors in the brainstem and hypothalamus play a role in how we perceive signals from our internal organs

Current drugs that are on the market have a long half-life in the blood and do not readily cross the bloodbrain barrier (BBB)
