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The insulinotropic effects of GIP are dramatically attenuated in T2D patients (52, 53), and this is believed to be a major contributing factor to impaired postprandial insulin secretion in these individuals
doi: 10.1038/nrneph.2015.173
But knowing it exists helps you understand why the curves look the way they do and why accumulation follows such predictable patterns
Her ISL stage reverted to stage 1
Thus, the GLP-1 assay measures uncleaved and cleaved 36 amino acid amidated species of endogenous GLP-1
