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28 The effect of weight loss through these recently approved, but increasingly used, drugs on nephrolithiasis risk in patients with known stone disease is not well understood
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Tirzepatide targets two receptors (GLP-1, GIP) and produced 22.5% weight loss

At the same time, some epidemiological studies do show that GLP-1RAs can have a protective effect, delaying the progression of dementia in the treatment of patients with T2DM

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