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Ensure you are not skipping meals, as low blood glucose can trigger headaches

While these mechanisms make them highly effective, they also predispose patients to gastrointestinal adverse effects, such as nausea, vomiting, abdominal discomfort, and constipation

Semaglutide activates glucagon-like peptide-1 receptors to reduce hunger and slow stomach emptying, while topiramate acts on multiple brain regions involved in appetite control and energy expenditure

Advance to the next dose tier only after four consecutive weeks at the current dose with all four tolerability criteria met

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