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Consistently, regardless of the initial positions of palmitate either located in the membrane as seen in the cryo-EM structure or placed outside of the membrane, our MD simulations found that the -carboxylate spacer stably inserted into the TM1-TM2 cleft and the 16-carbon palmitic chain is deeply buried in the receptor-lipid interface, contributing multiple strong contacts to stabilize the complexes (Supplementary Fig

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Another study found that psychiatric AEs only accounted for 1.2 % of total reports for semaglutide, liraglutide, and tirzepatide [47,48], although rare case reports have suggested suicide as a serious psychiatric AE of semaglutide 2.4 mg [[49], [50], [51], [52]]