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Thyroid tumors have been reported in rodents given GLP analogs and thyroid C-cell hyperplasia has been reported in humans

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Most studies investigated correlations with plasma GLP-1 levels or administered GLP-1 agonists (6) or GLP-1 antagonists (5), or a combination (1)

In this setting, if gluconeogenic flux and/or glycogenolysis are also compromised as a result of inadequate substrates for gluconeogenesis (e.g., reduced AAs), subnormal glycogen storage (low caloric intake), or reduced counterregulatory hormones, hypoglycemia at late postprandial time points could ensue

Several studies have shown that the clear link between glucose metabolism and GLP-1 through the protein kinase A (PKA) pathway [25-27]