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Notable are the EMPA-REG OUTCOME trial, which showed a significant reduction in aminotransferases with empagliflozin 47 , and a meta-analysis of ten randomized controlled trials with 573 participants that confirmed the superiority of SGLT2 inhibitors over other antihyperglycemic agents in terms of improvement in hepatic and metabolic parameters 48

The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which evaluated once-weekly semaglutide 2.4 mg for weight management, demonstrated significant weight loss (approximately 15% in STEP 1) that could indirectly affect hormone levels, though testosterone was not systematically reported in these publications

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