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Data were normalized to maximum concentrations of GLP-1 or GIP (100%) and no ligand (0%) and analyzed by nonlinear regression (sigmoidal concentration-response) and plotted using GraphPad Prism 7 software

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Their change in creatinine was compared to patients with no GLP-1 exposure who had office visits in the same period

Samples are then analyzed using LC-MS to detect degradation products or structural changes

Weight Loss: The average percent weight loss from patients starting weight after these 17 months at the maintenance dose was: -15% weight loss from baseline body weight at 68 weeks at the 2.4mg dose -In a two year follow up study, those who continued to take semaglutide at the 2.4mg dose were able to maintain an average of 15.2% of their initial weight