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glp 1 anhedonia GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Weight GLP-1 side effect Anhedonia
Description
These drugs were initially developed for the treatment and/or management of diabetes, but scientists thought this drug could be a direct cure for obesity as well
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de van der Schueren MAE, Laviano A, Blanchard H, Jourdan M, Arends J, Baracos VE
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Gut microbiome composition may influence GLP-1 production, though evidence in humans remains preliminary
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Under typical physiological conditions, GLP-1 has a half-life of only 12 min due to rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which cleaves GLP-1 and renders it biologically inactive
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Eur J Pharmacol 2003
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