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32 Nevertheless, some aspects of the 3142 segment of the GIP remain undiscovered, as GIP (330) is an antagonist while GIP (342) is a partial agonist of GIPR

RakipovskiGRolinBNhrJKleweIFrederiksenKSAugustinRet alThe GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE(-/-) and LDLr(-/-) mice by a mechanism that includes inflammatory pathways

Moreover, GLP-1RAs can alleviate vascular remodeling expressed as neointimal hyperplasia after induced vascular injury

Tirzepatide is a dual GLP-1/GIP receptor agonist

Drugs like semaglutide and tirzepatide have shown significant benefits for both type 2 diabetes and obesity