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Hepatic Uncommon (0.1% to 1%): Acute gallbladder disease (cholelithiasis, biliary colic, cholecystectomy) Hypersensitivity Common (1% to 10%): Hypersensitivity reactions (e.g., urticaria, eczema) Postmarketing reports : Anaphylaxis, angioedema Immunologic Very common (10% or more): Anti-drug antibodies (up to 51%) Common (1% to 10%): Neutralizing antibodies Local Common (1% to 10%): Injection site reactions Metabolic Very common (10% or more): Hypoglycemia (up to 19%), decreased appetite (up to 11%) Common (1% to 10%): Hyperglycemia Hypoglycemia (glucose level less than 54 mg/dL) occurred more frequently when this drug was used in combination with a sulfonylurea (up to 13% of patients in a clinical trial)