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Compounded semaglutide uses the same active ingredient, semaglutide, but it is prepared by a compounding pharmacy rather than manufactured by Novo Nordisk

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How Much Weight Loss Do GLP-1 Drugs Produce Across the three reviews, tirzepatide (Mounjaro and Zepbound), semaglutide (Ozempic, Wegovy, and Rybelsus), and liraglutide (Victoza and Saxenda) all led to notable weight loss over one to two years compared with placebo