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Since arriving on the market in 2005 for the treatment of Type 2 diabetes, Circana said, the class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1s) have upended diabetes treatment and revolutionized how doctors and consumers approach weight management. These medications are designed to mimic the effects of a naturally occurring hormone that helps regulate blood sugar and slows digestion, which promotes the feeling of satiety, Circana added, noting that the first GLP-1 medication was approved for weight loss in 2014

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Increased Ca2+ levels also promote transcription of the proinsulin gene, thereby increasing the insulin content of the cell