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Efficacy, safety, and tolerability of oral semaglutide versus placebo added to insulin with or without Metformin in patients with type 2 diabetes: the PIONEER 8 trial

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From a translational perspective, preclinical studies have identified systemic and intra-cranial doses of exendin-4 that attenuate cocaine taking and seeking [121, 128, 132] and do not produce notable metabolic or adverse effects associated with GLP-1 receptor agonists in humans and rodents [119, 120, 177]

If you do this, use a fresh syringe for the transfer, swab all stoppers, and record the combined volume and total tirzepatide content so you can calculate the new concentration accurately