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Short-acting GLP-1RAs, which present a half-life of 34 h, include exenatide, administered twice daily, and lixisenatide, administered once daily, are both exendin-4 derivatives

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What Exactly Is Retatrutide and How Does It Work for Weight Loss Research Retatrutide (also designated LY3437943) is a synthetic 39-amino acid peptide that simultaneously activates three receptor pathways: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and the glucagon receptor