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In the SURMOUNT-1 trial, tirzepatide produced dose-dependent weight reductions, with average losses approaching or exceeding ~20% at higher doses in adults with obesity who did not have diabetes, numbers that markedly exceed historical pharmacotherapy benchmarks
Microbiome support: Prebiotic fibers feed beneficial gut bacteria, influencing metabolic signaling through multiple pathways beyond GLP-1
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Medication interactions: Tirzepatide may reduce the effectiveness of oral contraceptives
