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The herbal wellness patch category lacks the clinical trial evidence base of FDA-approved medications

The Menopause Society identifies specific safety considerations for compounded preparations

I expect that there will be at least one arm of the phase 3 trials Lilly will run, and I suspect they may also try a 12mg arm and probably a 6mg arm as they tend to aim for 3 approved doses for weight loss indications

However, post-marketing surveillance has identified isolated case reports of suicidal ideation temporally associated with these medications

The drugs skyrocketed in popularity in 2023 as they helped patients shed significant weight, despite hefty price tags, mixed insurance coverage and a handful of unpleasant side effects