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In this case, the main producers were Clostridium species, which express an enzyme (7-HSDH) that performs this conversion

doi: 10.1038/s41598-021-97967-0 195 InaishiJSaishoY

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Moreover, ARAP3 expression was found to be significantly altered with iNOS expression post-GLP-1R activation by different concentrations of Ex-4 (Figure S2A-B), but the systemic regulatory mechanism of microglial inflammatory interference by GLP-1R activation requires further verification