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Other smaller studies that Fessel analyzed had mixed results

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Factors Influencing the Right Dose Several factors determine the appropriate semaglutide dose for weight loss : Body weight and composition: Heavier patients may require higher doses to achieve desired outcomes

JANUMET is not recommended in patients with an eGFR between 30 and less than 45 mL/min/1.73 m2 because these patients require a lower dosage of sitagliptin than what is available in the fixed combination JANUMET product