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In order to achieve the purpose, the technical scheme provided by the invention is as follows: (1) Preparation of compound 2: arg34GLP-1 (9-37) is taken as a starting material, side chain modification is carried out on 26-Lys of the Arg34GLP-1 (9-37) and the compound 1, acylation coupling reaction is carried out under certain reaction pH conditions, and solid is precipitated by adjusting isoelectric point of reaction liquid after post-treatment to obtain a compound 2

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8 There has not been a study evaluating tirzepatide use in kidney outcomes as a primary endpoint in subjects with type 2 diabetes and chronic kidney disease