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Loss of muscle mass and strength not only impairs mobility and quality of life, but also worsens insulin resistance, accelerates cardiometabolic decline and increases mortality risk

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Despite this being prominent in the news, the first medication mentioned by GPs and IMs when asked Which drugs for managing of patients living with obesity are you aware of, even if you have not prescribed them? was, in 54% of responses, the much older and less effective orlistat and its brand names Xenical and Alli (figure 1)