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Description
What they are and how theyre used What are GLP-1 agonists

When considering its development, one may expect that initial investigations and clinical trials would focus on its metabolic benefits, gradually revealing its potential for weight loss
doi: 10.1016/S0140-6736(21)01324-6 Summary Keywords glucagon, GLP-1, obesity, co-agonist, weight loss Citation Hope DCD, Vincent ML and Tan TMM (2021) Striking the Balance: GLP-1/Glucagon Co-Agonism as a Treatment Strategy for Obesity

It was discovered to be an acute phase reactant in the 1940s and noted to be synthesized in the liver in the 1960s

The combination is generally well-tolerated, though both medications can cause GI side effects
