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Treatment lines begin at a low starter dose of 3mg once daily for 30 days to let the stomach adapt, step up to 7mg once daily for another 30 days, and finally step up to the 14mg therapeutic maintenance tablet

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The modification causes it to bind to albumin, protecting it from metabolic degradation and decreasing its renal clearance, thus prolonging its half-life

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Simultaneously, it suppresses glucagon secretion, which reduces hepatic glucose production