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The exact reason for this isnt clear

Between 3 and 12 months post-index, fewer patients received the 7.0-mg formulation (55.5 to 37.5%) in this study while dispensation of the 14.0-mg formulation increased (26.0 to 56.3%)

There were several study limitations identified by the researchers

Finally, TRANSCEND-T2D-3 (NCT06297603) will compare retatrutide to placebo over 14 months, in people with inadequately controlled T2D and moderate-or-severe renal impairment on basal insulin
