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Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)

While a few studies found no changes in urination, the majority show beneficial effects, like less frequent and urgent peeing

For 503A pharmacies (state-licensed compounding pharmacies), the deadline to stop compounding tirzepatide injections was February 18, 2025

The median duration of response was 5.8 months

Focus on small portions (e.g., 8 fl oz), as large volumes of liquid in the stomach can trigger nausea