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Repatha (evolocumab) is a PCSK9 inhibitor that cuts LDL by ~60% when statins aren't enough
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This study 1) highlights the role of cholesterol in regulating GLP-1R responses in vivo

“Millions of Americans could benefit from GLP-1s, but clinical trials suggest patients need to stay on these drugs to experience sustained benefits,&rdquo

Summary GLP-1 RAs alter gastrointestinal motility at all levels of the GI tract, with delayed gastric emptying being the most well characterized
