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(2025) [6] investigated the effect of treatment with tirzepatide on HFpEF (Table 3)

While tirzepatide's glucose-dependent mechanism reduces hypoglycemia risk compared to some other diabetes medications, any intervention affecting glucose metabolism warrants monitoring

This macro pattern works best: center meals on protein, fiber-rich vegetables, and moderate portions of complex carbohydrates

Nausea, bloating, constipation, and fatigue are common, especially during the initial stages or when increasing the dose too rapidly

Strata are defined as trial-level cardiovascular risk (SURPASS-4 forms one stratum, and all other trials form one stratum)